Reduced Hyaluronan in Keloid Tissue and Cultured Keloid Fibroblasts
نویسندگان
چکیده
منابع مشابه
Transforming Growth Factor Beta Gene Signatures are Spatially Enriched in Keloid Tissue Biopsies and Ex vivo-Cultured Keloid Fibroblasts.
The keloid lesion is recognised as a spatially heterogeneous mass both in cellular and acellular composition and biological activity. Here, we have utilised a bioinformatic approach to determine whether this spatial heterogeneity is also evident at the molecular level and to identify key upstream regulators of signalling pathways enriched in the lesion in a spatially-restricted manner. Differen...
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BACKGROUND Keloids are defined as a kind of dermal fibroproliferative disorder resulting from the accumulation of collagen. In the remodeling of extracellular matrix, the balance between matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) is as critical as the proper production of extracellular matrix. We investigate the role of TIMPs and MMPs in the pathoge...
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BACKGROUND Keloids are thick fibrous scars that are refractory to treatment and unique to humans. The lack of keloid animal models has hampered development of effective therapies. The authors' goal was to develop an animal model of keloids using grafted engineered skin substitutes composed of keloid-derived cells. To demonstrate the model's utility, differences between deep and superficial kelo...
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Hydrocortisone stimulates proliferation and System A amino acid transport in cultured human fibroblasts, while decreasing production of collagen. Fibroblasts isolated from keloid tissue have an unusual glucocorticoid response; they are hyporesponsive with regard to proliferation and collagen production but hyperresponsive with regard to the induction of System A amino acid transport (Russell, J...
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Purpose: To report the clinical presentation, histopathologic findings, and surgical treatment in a series of cases with primary corneal keloid. Case Reports: Six Iranian patients (a father and two sons, a mother and her daughter, and one isolated male patient) without any history of corneal trauma or systemic diseases were clinically and histologically evaluated for a slowly-growing, white opa...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2000
ISSN: 0022-202X
DOI: 10.1046/j.1523-1747.2000.00950.x